I mean lets see the defeats of each remaining villain
- Syndrome
- Chopped up to pieces by a plane turbine, plane turbine explodes
- Yzma
- Turned into a cat
- Madam Mim
- Came down with a Merlin virus
- The Horned King
- Sucked into a cauldron
- Oogie Boogie
- Unravelled, all bugs die
- Mother Gothel
- Rapidly ages, falls to her death, turns into thin air in the middle of her fall
In the end I think Syndrome had the harshest death in Disney Villain HISTORY